Development, characterization and in VIVO evaluation of diffusion controlled transdermal matrix patches of a model anti-Inflammatory drug

In the current research, diffusion controlled transdermal matrix patches of Lornoxicam, an anti-inflammatory drug was developed by solvent casting method using hydrophilic and hydrophobic polymers in different ratios tween-80 span-80 as permeation enhancers. Formulated were characterized for physicochemical parameters terms moisture loss, content, film thickness strength, uptake loss moisture, transmission water vapor etc. All these found be satisfactory. In-vitro studies formulated performed Franz cells. The rate followed zero order kinetics with super case II transport diffusion. Based on data, best formulation selected used further stability analysis. Developed stable at temperature humidity settings properties content. optimized also evaluated in-vivoanti-inflammatory analgesic activity suitable animal models. results all in-vitro in-vivo justify selection route systemic delivery Lornoxicam to overcome its shortcomings when administered orally.